Freedman Lab

Research focus

NIH R01 · 2024

Trans-omics Analysis of African American Deceased Donor Kidneys for Transplant Outcomes.

. Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Kidney-risk variants (KRVs) in the apolipoprotein L1 gene (APOL1) are present only in African-derived populations, including African Americans. More than 30% of cases of end-stage kidney disease (ESKD) in African Americans are attributable to these variants. APOL1 KRVs also contribute to the more rapid failure of transplanted kidneys from African American deceased donors. However, only ~20% of those with APOL1 high-risk genotypes develop ESKD, and only a similar portion of transplanted kidneys from deceased donors with APOL1 high-risk genotypes fail rapidly.…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.