NIH R01 · 2024
Dual Functionality of Ceramide in Human Microvascular Endothelial Function
Project Summary Elevated levels of plasma ceramide are an independent risk factor for major adverse cardiac events (MACE) and are associated with cardiovascular diseases including coronary artery disease (CAD) and heart failure with preserved ejection fraction (HFpEF). Endothelial microvascular dysfunction, the loss of nitric oxide (NO)- mediated dilation to flow (flow-induced dilation; FID), precedes the development of CAD and occurs following chronic exposure to exogenous ceramide. During disease, following acute stress (e.g. high pressure), or after chronic ceramide treatment, FID is maintained by utilizing mitochondrial-derived hydrogen peroxide (H2O2). Although effective at eliciting…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.