NIH R01 · 2025
Sex-based contributors to vulnerability to Alzheimer's disease: a multimodal imaging study
Project Summary / Abstract Nearly 2/3 of people with Alzheimer's disease (AD) are women, and AD has a more aggressive phenotype in women. Women with AD suffer a faster rate of cognitive and functional decline than do men, and women are more impacted than men by common genetic variants such as APOE-ε4 which increase AD risk. The first signs of AD pathology are present decades prior to symptom onset, and multiple lines of research have implicated the menopausal transition as a time of emerging vulnerability to AD for women. However, we lack a fundamental understanding of sex differences in the brain circuitry most vulnerable to AD and how these differences relate to the onset and spread of AD…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.