NIH R01 · 2024
For an organism to survive, its proteins must adopt a diversity of conformations in a challenging environment where macromolecular crowding can derail even robust biological pathways. This situation becomes critical when considering proteins with energetic folding landscapes that permit many conformational states. In these cases, the environment can clearly influence the conformation by favoring one pathway over another. Because the aggregating proteins that are responsible for neurodegenerative diseases like Alzheimer’s and Parkinson’s diseases often have identical sequences in healthy and diseased individuals, differences in cellular environment are responsible for the conformational…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.