NIH R01 · 2025
Structure-based functional annotation of microbial genomes
Abstract One of the most pressing challenges in modern biology is that of translating the massive amounts of information on biological sequences that has been made available by recent advances in sequencing technologies, into corresponding insights into the behavior of biological systems. Determining the functions and physiological roles of proteins remains a major component of this challenge; for many species, especially non-model microbes such as microbial pathogens, the fraction of the proteome consisting of poorly annotated proteins may approach 50%, severely limiting our ability to even identify mechanisms of pathogenesis and potential therapeutic targets. The massive number of poorly…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.