NIH R01 · 2024
Central Mediation of Growth Hormone Effects in Humans
PROJECT SUMMARY GH and IGF-1 are well known to act on peripheral tissues to importantly influence growth, metabolism and body composition. Recently, however, our preliminary work and other data in mice have suggested that central effects of GH on the orexigenic hypothalamic neuropeptide AgRP (agouti-related protein) may be another important mechanism by which GH exerts its nutritional and metabolic effects. AgRP neurons express GH receptors and in mice, GH was shown to activate AgRP neurons to produce orexigenic responses. The current project stems from our studies in acromegaly, a human model that provides unique insights into the mechanisms of GH/IGF-1 effects. We found novel evidence…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.