Frasca Lab

Research focus

NIH R01 · 2024

Metabolic deficits and immune dysfunction in aging people living with HIV

Aging and HIV are characterized by systemic chronic inflammation (inflammaging) and chronic immune activation (IA), both associated with cell senescence, functional impairment of immune cells and reduced immunity to infections and vaccines. Aging and HIV are also associated with metabolic changes such as decreased insulin sensitivity, dysregulated nutrient uptake and dysfunctional mitochondria. As a consequence of these changes, metabolites involved in glucose and fatty acid metabolism are released in blood. Some of these metabolites have been shown to be positively associated with inflammaging and therefore expected to be also associated with dysfunctional immunity. In people living with…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.