Franks Lab

Research focus

NIH R01 · 2024

Collaborative Research: DMS/NIGMS 2: Methods for Systematic Analysis of Post-transcriptional Regulation in Single Cells

PROJECT SUMMARY (See instructions): Proteins are the drivers of molecular activity in the cell, but we still lack a comprehensive understanding of the mechanisms by which cells regulate protein abundances. A long-standing question has focused specifically on the mechanisms and degree of post-transcriptional regulation, which also determines the degree to which mRNA levels can be used to predict protein abundances. For example, mRNA levels generally correlate with protein abundance across genes, but that mRNA-protein correlations can vary significantly within genes across conditions, due in part to post-transcriptional regulation, such as regulation of protein synthesis and degradation.…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.