NIH R01 · 2025
Mechanisms and Structures of Pseudomonas aeruginosa hibernating ribosomes
Pseudomonas aeruginosa is an opportunistic pathogen that causes persistent biofilm infections. Biofilms are difficult to treat with antibiotics, in part, because biofilms contain heterogeneous subpopulations of cells, including dormant bacteria in zones that are depleted in oxygen or nutrients. The dormant bacteria are not sensitive to antibiotics that target active metabolism. When bacteria enter dormancy, they undergo metabolic reprogramming to reduce energy expensive processes, but preserve essential macromolecules, including ribosomes, which are maintained in an inactive state. Signaling of bacterial growth arrest is mediated, in part, by the stringent response, which in turn controls…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.