NIH R01 · 2025
Mechanisms of serotonin and serotonin receptor biology in normal and glaucomatous retinas
PROJECT SUMMARY Glaucoma is a progressive disease of retinal ganglion cells (RGCs) and their axons. Some evidence suggests that oral SSRIs (selective serotonin reuptake inhibitors), which increase serotonin (5-HT) levels, may have a protective effect against progression of open angle glaucoma. To understand the mechanism of this potential protection, we assessed RGC expression of serotonin receptors (HTRs) in mouse and human scRNA-seq datasets. In mice, Htr1b is expressed in RGCs at a high level and preferentially expressed in alpha RGCs (αRGCs). In humans, HTR1B is expressed in RGCs, suggesting a conserved function. In mouse retinal tissue, we detected Htr1b transcript in the ganglion cell…
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