NIH R01 · 2024
Technology Development for Biological Imaging with XFELs
Project Summary / Abstract Determining the structure and conformational dynamics of large protein complexes as well as other biological nanoparticles at room temperature with near atomic resolution has the potential to greatly impact structural biology and our knowledge of biomolecular function and interactions. A major bottleneck in structural biology is that while many critical cellular functions are performed by membrane proteins, they have proven intractable to structure determination by traditional x-ray crystallography, in which x-ray radiation damage is mitigated by spreading the radiation dose over many molecules in a crystal. Consequently, most membrane protein structures remain…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.