NIH R01 · 2024
Alzheimer's Disease (AD) and related dementias (ADRD) are characterized by progressive structural changes of brain tissue that results in a debilitating loss of cognitive and functional abilities and has profound social and economic implications. While hallmark AD pathology (e.g. beta amyloid depositions and neurofibrillary tangles) are remarkably pronounced at the cellular level, there are currently no successful non- invasive brain imaging techniques to report these microstructural changes. Diffusion magnetic resonance imaging (dMRI) is a widely available non-invasive clinical imaging method with this potential, as it is sensitive to the subtle motion of water within the complex brain gray…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.