NIH R01 · 2025
Chaperone-Mediated Autophagy in Cardiac Fibrosis
ABSTRACT Repair of the infarcted heart is dependent on timely activation and de-activation of fibroblasts and myofibroblasts. In the infarcted myocardium, fibroblasts undergo dynamic phenotypic transitions that require rapid turnover of their intracellular proteins. This constant renewal of the proteome involves not only transcriptionally-driven activation of protein synthesis, but also selective patterns of protein degradation. Chaperone-Mediated Autophagy (CMA) can selectively remove specific proteins to terminate their function, regulating a range of cellular processes, including survival, proliferation and differentiation. Our preliminary data show that myofibroblast-specific disruption…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.