NIH R01 · 2024
Project Summary Prostate cancer (PCa) incidence and mortality remain significantly higher in African American (AA) men compared to Caucasians (CA). Although socioeconomic factors may contribute to such differences, recent studies suggest that biological factors could potentially explain racial disparities (RD) in PCa. A few high- penetrance genes (HPG) have been found to predispose to high risk of PCa in AA men. These include EphB2 mutations. EphB2 is a tyrosine kinase (RTK) receptor that binds to the Ephrin ligand and initiates bidirectional signals that affect both receptor (forward signaling) and Ephrin-expressing cells (reverse signaling). Our preliminary observations suggest a…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.