NIH R01 · 2024
The Paracrine Regulation of Mast Cells During Biliary/Cholangiocyte Repair and Damage
Cholangiopathies, including primary sclerosing cholangitis (PSC) are cholestatic liver diseases that target cholangiocytes. No definitive treatments for PSC exist and curative measures are elusive, thus translational studies are critically needed. PSC is characterized by ductular reaction (DR) encompassing enhanced bile duct mass, biliary senescence, inflammation, peribiliary fibrosis and increased portal mast cell (MC) presence/activation. During liver damage, MCs migrate to the liver and reside near damaged/senescent bile ducts and inhibition of biliary-derived senescent associated secretory phenotypes (SASP) reduces PSC phenotypes in mice. The exact source of MC infiltration/activation…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.