NIH R01 · 2024
Discovery of Molecular Probes and Therapeutic Leads, Equip Supp
ABSTRACT The goal of this supplement to R01 GM132460 will be to support the toolkit being developed under the parent award through acquisition of a preparative HPLC instrument. The goal of the parent R01 is to improve the practicality, generality, tunability and scope of tetrazine ligation. We will develop a new generation of catalysts and reagents for tetrazine cross coupling and will apply these tools to chemical glycobiology applications. We will continue to develop novel tetrazines that can serve a dual role in enabling protein purification followed by subsequent site-selective bioorthogonal chemistry, and we propose to develop efficient catalytic methods for ‘turning on’ rapid…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.