NIH R01 · 2025
Mechanisms of Variant ER-alpha Function in Breast Cancer
PROJECT SUMMARY / ABSTRACT Estrogen receptor-alpha (ER), a member of the nuclear receptor family of transcription factors, drives proliferation of breast cancer cells and is expressed in the majority of breast cancers. Tumors that express ER account for the greatest number of breast cancer associated mortalities. While targeting the ligand- dependent functions of receptor is a successful approach in the clinical management of breast cancer, ER can be activated by other means. This alternative activity of ER can promote ligand-independent properties and our lack of understanding of this activity creates a barrier to the clinical challenge of therapy resistance. We have found that…
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