NIH R01 · 2025
Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV (TRIUMPH)
Project Summary/Abstract With the advent of modern antiretroviral therapy, life expectancy in people with HIV (PWH) now approaches that of the general population. Nonetheless, PWH continue to experience earlier onset and accelerated progression of complications of aging, including impaired physical function and frailty, which in turn may predispose to morbidity, mortality, and reduced quality of life. While exercise is the mainstay of therapy to prevent and to treat these conditions, we have shown that PWH display a limited clinical and biologic response to exercise as compared to uninfected controls. We have further found that long-term adherence to exercise among PWH is limited, even…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.