NIH R01 · 2025
Retinal neurovascular protection by boosting efferocytosis
Project summary/abstract: Our research focuses on identifying cellular mechanisms and therapeutic targets for retinopathies caused by ischemia or trauma including diabetic retinopathy, retinal artery or vein occlusion and traumatic optic neuropathy. A shared pathogenic event of these diseases is the myeloid cell response to retinal injury. In this project, we will study ‘efferocytosis’, which refers to the process by which myeloid cells (macrophages/microglia) clear dead cells by ‘eating’ them. In pathological conditions including stroke, atherosclerosis, and cancer, efferocytosis is thought to promote resolution of inflammation by clearance of dying cells; however, its role in retinopathy…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.