NIH R01 · 2025
Retinoid Metabolism in the Adult Heart and Heart Failure
Project Summary This proposal examines the previously unaddressed role of altered retinoid metabolism in heart failure (HF). We have recently shown that in both idiopathic dilated cardiomyopathy (IDCM) and experimental heart failure (HF) there is up to a 40% decline in the cardiac levels of the vitamin A metabolite and potent hormone, all-trans retinoic acid (ATRA), despite adequate vitamin A. We have also shown that direct administration of ATRA prevents HF, in response to pressure-overload. However, implementing ATRA therapy for HF could face headwinds, given the pleiotropy of ATRA signaling and the limited half-life of ATRA in the circulation. Alternatively, therapeutic specificity might…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.