NIH R01 · 2024
Unlocking the cidal activity of echinocandins against Aspergillus fumigatus
Invasive aspergillosis (IA), caused mainly by A. fumigatus, is the most prevalent invasive mold infection of immunocompromised individuals and is associated with mortality rates of 35-90%. Only three classes of anti- Aspergillus drugs exist. The global rise of resistance to the triazole class and the unacceptably high patient toxicity of the polyene class limits the use of two of these. The remaining class, the echinocandins, are generally considered effective therapeutic agents as their target is fungus-specific (cell wall biosynthesis) and they exhibit low toxicity. However, the echinocandins are not fungicidal for Aspergillus species and a paradoxical effect of treatment, characterized…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.