NIH R01 · 2025
HCMV infection downregulates nidogen 1 and myelin protein zero
ABSTRACT Human Cytomegalovirus (HCMV) is a leading cause of congenital birth defects. The most common sequela observed in symptomatic infants is sensorineural hearing loss (SNHL). SNHL is also observed, somewhat perplexingly, during early childhood, developing over a period of years in children born hearing competent and asymptomatic for infection at birth. The most abundant peripheral nervous system (PNS) myelin protein, myelin protein zero (MPZ), is largely responsible for compaction of the PNS myelin sheath. Charcot-Marie-Tooth Type 1B and Dejerine-Sottas syndromes patients, with mutations in MPZ, frequently suffer from late-onset SNHL, similar to that observed in HCMV…
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