Dempsey Lab

Massachusetts General Hospital

Boston · United States

NIH-funded
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NIH R01 · 2025

Multimodality Adaptive Intervention for Post-Inpatient Hospitalization Suicide Risk Reduction

ABSTRACT Over 48,000 Americans die by suicide each year, making suicide the 11th leading cause of death across all ages. The highest-risk time for suicidal behavior is the three months after inpatient psychiatric hospitalization, during which engagement with traditional outpatient care is low. Recent real-time monitoring research has revealed that suicidal thoughts fluctuate rapidly, over hours or even minutes, highlighting the need for dynamic interventions that adapt to time-varying changes in risk. We recently developed a just-in-time adaptive intervention (JITAI) that promotes coping strategy use during periods of elevated suicidal thinking. Our recent micro-randomized trial (MRT; N=71…

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