NIH R01 · 2024
Defining mechanisms of gammaherpesvirus-driven genomic instability in B cells
PROJECT SUMMARY Gammaherpesviruses (GHVs) establish lifelong chronic infections that place the host at risk for numerous cancers. During chronic infection, GHVs express viral gene products that stimulate host-cell proliferation and differentiation, processes thought to facilitate long-term latent persistence and contribute to tumorigenesis. However, GHVs are not acutely transforming, and cancer is rare given the high incidence of infection among adult humans, estimated at more than 95% for Epstein-Barr virus (EBV). This suggests that host cells are equipped with an intrinsic resistance to GHV-driven proliferation and cellular immortalization. In work performed during the previous funding…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.