NIH R01 · 2025
Project Summary The overall objective of this project is to evaluate the potential of magnetic resonance (MR) measures of bioenergetics and microvascular function to track disease progression and treatment in dystrophic muscle. Duchenne muscular dystrophy (DMD) is characterized by progressive muscle weakness, fatigue, deteriorating functional capabilities, loss of independence, and early death. Muscles in individuals with DMD are deficient in dystrophin, which is accompanied by a lack of sarcolemma-localized neuronal nitric oxide synthase mu (nNOSμ). Gene therapies aimed at delivering micro-dystrophin genes are emerging as viable therapeutic options in DMD; however, a number of questions…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.