NIH R01 · 2025
Molecular Basis for the TREX-2 mRNA Nuclear Export Pathway
Project Summary Nuclear export of mRNAs through the nuclear pore complex (NPC) is an obligatory pathway for eukaryotic gene expression, which is regulated by various cellular stress conditions such as viral infections and immune responses. During gene expression, the TREX (TRanscription and EXport) complex is recruited co- transcriptionally and pre-mRNA processing further mediates TREX assembly on the transcript. Through the combined action of the TREX complex and other mRNA export factors, the major mRNA export receptor NXF1- NXT1 heterodimer is recruited to the mRNA. At the nuclear face of the NPC, NXF1-NXT1 bound to mRNA can either dock at the NPC or associate with an NPC-anchored…
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