NIH R01 · 2025
PROJECT SUMMARY Given the importance of mutations in oncogenes and tumor suppressor genes, it has been widely assumed that the mere accumulation of mutations is the primary process to explain cancer incidence. However, cancer is predominantly a disease of aging, with its incidence remaining low until the fourth decade of life, undergoing exponential growth thereafter. Furthermore, cells carrying well-characterized oncogenic mutations can be found across normal human tissues, and can persist for decades without ever developing cancer. Our current understanding of what factors govern this decades-long latency and eventual failure in aged tissues are extremely limited. A compelling argument to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.