NIH R01 · 2025
Long-term Phenotypic Alteration in the Lung Epithelium Following Early-life RSV Infection
Project Summary/Abstract Severe RSV-bronchiolitis infection has been associated with the development of asthma later in childhood. RSV is the primary cause of bronchiolitis in children worldwide, and it is considered the most impactful risk factor for asthma development among causative pathogens. The therapeutic options are limited. The mechanism by which early-life RSV (EL-RSV) infection predisposes to asthma later in life is unknown. Our studies will investigate the mechanism behind asthma development after EL-RSV infection by focusing on long- term lung epithelial cell alterations generated by epigenetic modification. We will specifically investigate the role of the innate cytokines…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.