NIH R01 · 2024
Overcoming epigenetic barriers to somatic cell reprogramming by the XPC DNA repair complex
PROJECT SUMMARY/ABSTRACT. Thymine DNA glycosylase (TDG) is a key enzyme in somatic cell reprogramming. TDG catalyzes DNA demethylation and reactivation of specific sets of genes to induce a pluripotent cell fate in somatic cells. However, there is a fundamental lack of understanding of how TDG is directed to its target genes to catalyze dynamic demethylation to facilitate their timely activation and thereby cell fate conversion. Thus, our understanding of epigenetic mechanisms of cell fate change remains incomplete. The long-term goal is to understand fundamental mechanisms by which factors such as TDG control processes requiring widespread epigenetic changes, including normal embryonic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.