NIH R01 · 2024
Histone chaperone networks for new and evicted histones
Project Summary Nuclear DNA is packaged into nucleosomes by histone proteins to create chromatin. The assembly of chromatin is not a passive process but requires the activity of a network of histone-chaperone proteins that facilitate histone stability, prevent aggregation, organize histone transport and facilitate their deposition. Histone chaperones must deal with new histones, and also with pre-existing histones that are evicted from chromatin. DNA replication, DNA transcription and access to other control elements in the genome require nucleosomes be either moved out of the way (slid) or removed, resulting in the eviction of pre-existing histones. Specific chaperones contribute to the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.