NIH R01 · 2024
ABSTRACT: The integration of electrochemical biosensors with microelectronics offers a unique avenue for miniaturized, low-cost systems that merge biomolecular sensing with digital computing, programming, and communication. Here we propose to integrate electrochemical aptamer-based sensors (“aptasensors”) into a microfluidic multi-well platform to enable multi-time-point, highly parallel readouts of cell death and cytokine secretion from intact tumor biopsies during and after drug treatment. Our platform will allow for gathering the large amounts of molecular data that are needed for machine learning approaches to drug testing. Cancer drug testing – a central process in cancer drug…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.