Flynn Lab

Medical College of Wisconsin

INTERNAL MEDICINE/MEDICINE

Milwaukee · United States

NIH-funded
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NIH R01 · 2024

Symptom Monitoring using Patient-Reported Outcomes to Optimize Medication Use (SyMPTOM)

PROJECT SUMMARY For the more than 200,000 women who develop hormone receptor positive breast cancer yearly, endocrine therapy for at least five years reduces cancer recurrence by nearly 50% and increases overall survival. Yet almost half of patients prescribed endocrine therapy fail to take all their pills. Education and reminder-based studies in this and other clinical settings have had disappointingly small effects on adherence, and more complex interventions have proven difficult to sustain. In this proposal, we focus on the pain, menopausal, and other symptoms that women describe as major barriers to endocrine therapy adherence. We have drawn on two complementary sets of research…

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