NIH R01 · 2025
Screening Strategies Among High-Risk Populations for Anal Cancer
The incidence of anal cancer has nearly doubled over the past decades, along with increased advanced disease and mortality. Persistent high-risk human papillomavirus (hrHPV) infection leads to anal high-grade squamous intraepithelial lesion (aHSIL), the precursor to anal cancer. Anal cancer risk is also exceptionally high among individuals with chronic impairment of the immune system and women with an history of high-grade anogenital tract diseases. Early detection of aHSIL, particularly among high-risk populations, is crucial to reduce cancer incidence and disease burden. However, the current recommendation for aHSIL screening is based on expert opinions, and research is scarce. Therefore,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.