NIH R01 · 2025
DIscovering SubPhenotypes and ENdotypes in pediatric SEpsis-induced MODS: the DISPENSE Study
Project Summary/Abstract Sepsis is a “syndromic” definition reflecting patients with great heterogeneity in age, comorbidities, pathophysiology, and inciting triggers. This heterogeneity likely contributes to a myriad of negative randomized controlled trials (RCTs). The identification of higher-risk subgroups (e.g., subphenotypes) within these heterogeneous disease states is a critical gap in knowledge prohibiting development of tailored treatments targeting subgroups with similar biology (e.g., endotypes). Despite years of research, aside from timely antibiotic administration, pharmacologic treatment has proven ineffective in decreasing mortality and morbidity in children with sepsis…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.