NIH R01 · 2024
Cholesterol homeostasis in the vertebrate retina
ABSTRACT: All eukaryotic cells require cholesterol (Chol) for survival and regulate their steady-state levels by balancing de novo synthesis, uptake of Chol-containing lipoproteins, and Chol efflux (i.e., “Chol homeostasis”). Hereditary defects in processes that affect normal Chol homeostasis comprise a family of diseases, some of which have pathological effects on the retina. Our current understanding of Chol homeostasis in the retina remains comparatively rudimentary. Other than Chol per se, how other circulating lipids and lipid-soluble molecules impact retinal Chol homeostasis remains largely unknown and unexplored. This Supplement project piggy- backs onto an already approved parent…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.