Fleischer Lab

Emory University

RADIATION-DIAGNOSTIC/ONCOLOGY

Atlanta · United States

NIH-funded
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NIH R01 · 2024

Synergistic advancements in MR thermometry and predictive thermal modeling towards improved characterization of human brain temperature

Project Summary Brain temperature regulation is crucial for neurologic function and recovery after ischemia and injury. Local brain temperature increases as small as 1-2°C significantly contribute to the extent of ischemia-induced brain damage, and dissociation of brain and body temperatures is a strong predictor of poor prognosis. While brain temperature is well-recognized as an important clinical parameter for neuroprotection, current brain thermometry has been limited to invasive temperature probes surgically implanted at a single location, making it impractical in most patient cohorts. Several magnetic resonance (MR)-based thermometry methods have been proposed and demonstrated in…

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