NIH R01 · 2025
Summary Alcohol related liver disease (ALD) and in particular alcohol associated hepatitis (AAH) is a leading cause of liver related deaths worldwide1. AAH involves metabolic alterations in hepatocytes and complex hepatocytes-stromal cell interactions. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Possible reason for that could be that the humans and rodents liver cells are significantly different in terms of hepatic lipoprotein2, bile acid 3 and in alcohol metabolism rates4. In human AAH, there is severe steatosis, hepatocyte apoptosis, Mallory-Denk hyaline inclusions, cholestasis and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.