NIH R01 · 2024
Abstract Type 2 diabetes (T2D) is a highly prevalent disease for which new therapies are needed. The adipocyte differentiation and lipid storage pathways are involved in rare and common forms of diabetes and are targeted by thiazolidinediones (TZDs), which are efficacious but cause undesirable complications. Designing better therapies to target adipocyte differentiation/lipid storage is impeded by incomplete knowledge of which genes in these pathways are relevant to T2D in humans, or how they might be modulated to achieve therapeutic efficacy. Disease-associated rare coding variants directly identify human disease-relevant gene modulations, and our recent study of 45,231 exomes suggested…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.