NIH R01 · 2025
Human neural stem cell and endothelial cell reciprocal interactions govern cell function
Project Summary Neural stem/progenitor cells (NSPCs) lie in close proximity to blood vessels in brain stem cell niches and after transplant to treat neurological conditions. This adjacency allows for considerable interaction between NSPCs and the endothelial cells (ECs) that form blood vessels, creating an interdependent and complex relationship between these cell types. Human NSPC (hNSPC) and human EC (hEC) interactions have not been well studied, creating knowledge gaps that hinder our understanding of human brain function and repair after injury. We used a tissue engineering approach with a a 3D scaffold mimicking brain properties to study hNSPC-hEC interactions. We found hEC contact…
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