NIH R01 · 2024
Beyond Urea Kinetics: Balancing Tradeoffs in Dialyzer Design for the Next 50 Years
The 548,000 Americans who rely on dialysis to stave off death from kidney failure suffer from malnutrition, inflammation, immune defects, and vastly increased incidence of coronary thromboses and pulmonary embolisms. Conventional hemodialysis cartridges are designed to remove urea, because urea removal is fundamental to dialysis quality metrics. However, urea is a largely non-toxic stand-in for other waste products, and urea-focused efforts fail to capture the complexity of dialysis in renal failure. One class of uremic wastes that are thought to contribute to the illness of dialysis patients is called "protein-bound uremic toxins" (PBUTs), such as indoxyl sulfate, kynurenic acid, and p-…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.