NIH R01 · 2025
Role of targeting ATPases BRG1/BRM in therapy of AML
Project Summary: BAF (BRG1/BRM-associated factor) complexes are ATP dependent chromatin-remodeling complexes which contain mutually exclusive, core ATPases, BRG1 (SMARCA4) and BRM (SMARCA2). The canonical (c) BAF complex subunits bind and allow transcription factors (TFs) and co-factors to gain access to the chromatin and modulate lineage-specific gene transcription in hematopoiesis. BRG1 is a dependency in AML cells, including those with MLL rearrangement (MLLr) or mutant (mt) NPM1, representing 40% of adult AML. Although Menin inhibitors (MIs) induce clinical remissions, most patients of AML with MLLr or mtNPM1 relapse with MI-resistant AML, based on adaptive, dysregulated…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.