NIH R01 · 2025
Mechanisms of Purkinje Cell Remodeling
PROJECT SUMMARY The ventricular conduction system (VCS) is essential for normal myocardial excitation and contraction. Diseases impacting VCS structure and function are responsible for a substantial burden of cardiovascular disease, including conduction slowing and block, and triggered and reentrant arrhythmias. In previous NIH- funded work, our laboratory established and characterized novel genetic tools to visualize the formation and function of the murine VCS and its constituent Purkinje cells, resulting in the identification of a novel transcriptional pathway critical for VCS development. We also used these tools to create and characterize innovative genetically engineered murine models…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.