NIH R01 · 2024
YAP/TAZ Regulation of Extracellular Matrix Homeostasis
ABSTRACT: The major goal of this grant application is to determine the molecular mechanisms by which YAP/TAZ regulate age-related skin dermal extracellular matrix (ECM) homeostasis. In human skin, dermal fibroblasts are responsible for the production, organization, and homeostasis of the collagen-rich dermal ECM, which comprises the bulk of the skin. In young skin, direct attachment to intact collagen fibrils allows fibroblasts to achieve a spread architecture, through mechanical forces generated by the assembly of the cytoskeleton. In this state, the YAP/TAZ pathway is active, which maintains a youthful anabolic phenotype with net ECM production. In aged skin, fragmented collagen fibrils…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.