NIH R01 · 2024
Molecular Regulation of Atherosclerosis Regression - Renewal
ABSTRACT Coronary plaques begin their progression in childhood, making their reversal an important clinical goal in adulthood. The understanding of mechanisms underlying atherosclerosis regression has been understudied compared to plaque progression. Atherosclerosis represents a failure to resolve the maladaptive immune response that maintains plaque growth through the accumulation of pro-inflammatory immune cells. The central inflammatory cell in the plaque is the macrophage (Mø) in the activated state. We previously showed that plaque regression in mouse models is characterized by the enrichment of Møs in the inflammation resolving state (which we will refer to as proR-Møs). We have…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.