NIH R01 · 2024
Mismatch Repair and Carcinogenesis
MISMATCH REPAIR AND CARCINOGENESIS PROJECT SUMMARY / ABSTRACT Defects in human mismatch repair (MMR) are the cause of Lynch syndrome aka hereditary non-polyposis colorectal cancer (LS/HNPCC), as well as 10-40% of various sporadic cancers. MMR corrects DNA polymerase misincorporation errors, suppresses recombination between non-allelic partially homologous DNA sequences, and functions as a lesion sensor in DNA damage signaling. The unrepaired errors in MMR-deficient cells lead to increased genomic mutations that drives tumorigenesis, while the lack of damage sensing results in resistance to several common chemotherapeutics. Conversely, MMR defective tumors appear to activate cellular innate…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.