NIH R01 · 2025
Targeting the chromatin binding domains of BPTF for neuroblastoma epigenetic therapy
ABSTRACT The goal of this proposal is to develop high-quality chemical probes to functionally annotate the epigenetic effector “reader” domains within Bromodomain PHD Finger Transcription Factor (BPTF) in neuroblastoma (NB) and to serve as new therapeutic leads. BPTF is an essential component of the nucleosome remodeling complex NURF. Nucleosome remodeling complexes are emerging as important anticancer drug targets due to their role in regulating chromatin accessibility and gene expression. We hypothesize that interfering with the chromatin binding of BPTF will disrupt oncogenic regulatory networks present in cancer cells. Our preliminary data supports a new tumorigenic role of BPTF in NB,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.