NIH R01 · 2025
The integrated mechanobiology and glycobiology of bone metastasis
Breast cancer is the most common cancer in women and frequently metastasizes to the skeleton, leading to poor prognosis. As existing therapies are relatively ineffective, a promising strategy could be to eradicate dormant tumor cells before they become activated. Indeed, tumor cells disseminate to the skeleton early during disease where they can remain quiescent for years or decades. Better understanding the mechanisms that regulate the fate of disseminated tumor cells prior to lesion formation promises to inform therapeutic options to prevent metastasis. Upon arrival in bone, tumor cells colonize osteogenic niches where they interact with mineralizing bone matrix and are protected from…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.