Firestein Lab

Columbia Univ New York Morningside

BIOLOGY

New York · United States

NIH-funded
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NIH R01 · 2024

The perception of odor blends and mixtures: Modulation, Inhibition and Enhancement of Olfactory Receptors alters perception of complex blends

Project Summary/Abstract This is a continuation of an existing program funded by an RO1 that seeks to understand fundamental questions about the nature of the olfactory stimulus and its discrimination by primary sensory receptors, in order to better grasp the nature of the signal being forwarded to the brain. We supplement the standard organic chemistry approach to odor classification with one that includes a biological perspective based in principles of medicinal chemistry pioneered in the pharmaceutical industry and drug development. This allows us to not only consider physical chemical characteristics of molecules but also how they interact with the many olfactory receptors. This work,…

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