NIH R01 · 2025
Metabolic Mechanisms of Recovery in Mild TBI
Project Summary The occurrence of concussion, or mild TBI, has been steadily increasing in incidence over the past decade. One possible consequence of concussion - post-concussion syndrome - can persist for weeks to months and result in life dissatisfaction for the patient and economic burden for society. With the development of new rodent models for mild TBI, we can now study the molecular mechanisms that mediate injury and/or protection from a single TBI. Our previous work identified significant changes in the guanine deaminase cytosolic PSD-95 interactor (cypin) after mild and moderate TBI, and in turn, discovered small molecule cypin activators that are neuroprotective in vitro and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.