Figee Lab

Icahn School of Medicine at Mount Sinai

PSYCHIATRY

New York · United States

NIH-funded
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Research focus

NIH R01 · 2025

Neurocomputational mechanisms and connectivity dynamics underlying obsessive-compulsive disorder and phenotypical differentiations

Project Summary/Abstract Obsessive-Compulsive Disorder (OCD) is a psychiatric disorder with a lifetime prevalence of 2-3% in the general population. It manifests in a variety of intrusive thoughts (obsessions), rigid decision-making and ritualistic behaviors (compulsions), with prolonged and disabling effects. However, the neural and computational mechanisms underlying the disorder or its differentiations remain unclear, so that misdiagnosis is frequent, and even when an appropriate treatment is established, about half the patients keep exhibiting disabling residual symptoms. In this project, we propose to use an innovative approach, relying on neurocomputational and connectivity analyses…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.

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